|
HEALTH
AND GENETICS REPORT
September
26, 2000
FOR "KYRA",
ALL HER
WHITE BROTHERS AND SISTERS
AND ALL
THEIR BEST FRIENDS
PREPARED BY:
Judy Huston
Health and
Genetics Chair
American
White Shepherd Association
ACKNOWLEDGEMENTS
First and foremost, I want to
acknowledge Dr. George Padgett for his devotion and commitment
to helping to prevent serious genetic diseases in dogs. Without
Dr. Padgett there would be no survey and no possibility of
making the kind of progress we can make in our quest to breed
healthy White Shepherds. His book is written in a style that
most dog breeders and pet owners can understand. It includes a
step-by-step method to help breed clubs improve the health of
their breeds. Dr. Padgett made himself available every step of
the way, beginning with doing our first seminar at the 1999 AWSA
National right through conducting our Results Seminar on
September 26, 2000. From all of us and all of our White Shepherd
friends, we thank you Dr. Padgett!
Next I want to acknowledge Joanne
Chanyi for she is someone I highly respect. She has been
breeding White Shepherds for over 30 years. When I approached
her with my idea to do a survey, she immediately began offering
support and encouragement. I would not have had the confidence
to proceed without her help. I'm not a breeder. I have no
first-hand knowledge or hands-on experience. My only
qualification is that I love these dogs, adore Kyra, and I
understood enough of Dr. Padgett's book to know a good idea when
I see it.
Denise Mencke took the time out of
her busy life to run all 1000 plus copies of the survey (5
pages, run off on both sides, with colored paper) and delivered
them to me at a meeting we were attending earlier this year.
Thank you Denise for this much-needed help. And thank you Karen
and Phil for your kind offer to take on this job if needed.
The initial mailing was going to
1,000 people and that's a lot of envelopes to stuff, stamp, and
mail. Pam and Michelle Koons spent a day with me getting the
first large mailing ready to go. They even delivered them to the
Post Office. Joanne Chanyi and Lynda Proulx took approximately
200 copies of the survey and mailed them in Canada. The White
Shepherd Club of Canada funded this. Thank you.
Then, when the deadline date for
returning the survey came and went, we had only about 427
surveys of the minimum 650 required. This is when Ronda Beaupre
took up the challenge. She told me she was going to do a mailing
to her puppy buyers and asked me if I could provide her with the
survey material. Could I? You bet! Ronda did the mailing and had
her puppy buyers return the surveys directly to me. Thanks to
this extra effort on Ronda's part, I added more dogs to our
slowly growing count.
Many of you jumped on board to
provide me with telephone numbers, e-mail addresses, suggestions
and encouragement. I'm almost afraid to mention names in case I
forget someone, but I'll do my best. Thanks to Mark Echterling,
Heather MacLeod (she put the survey on the WSCC Website), Trudy
Scofield, Jacki Wheeler-Stroud, Christina Tanner, Denise Mencke,
Diana Updike, Joanne Chanyi, Marion Lopizzio, Susan Ewart, Karen
Sayers, Chris Eggenberger, Debbie Martin, and all of you I
talked to by phone who gave me someone else's number to call.
Finally, we hit the magic 650
number and I was ecstatic as I called Dr. Padgett. I told him,
"We have 650!" He said, "Can you get any more?" More? How? I
asked him how many he thought we should have. He said 1,000
sounded good. We set up a date to meet that would give me about
3 weeks to add to the survey. Back to the drawing board – or I
should say, "the telephone." Normally, I spend very little time
on the telephone. Well, I began spending such a large amount of
time on the phone that my chiropractor asked me what I was doing
to my neck and shoulder. She gave me a puzzled look when I
replied that, "I'm doing a genetics survey for our White
Shepherds and spending a lot of time on the phone." She
suggested I change chairs and move the phone to the other side
of the desk. Why didn't I think of that?
When I met with Dr. Padgett for the
first time after completing the survey, we had 902 dogs. As it
happened, there were a number of tasks I needed to complete
before Dr. Padgett would require the final documents. So, each
time I went back for another meeting, I'd have more dogs entered
in the survey. A few days before our last meeting, I was still
almost 50 dogs short of the desired target of 1,000 dogs when
Jean Reeves decided she would do a Retroactive Test Mating for
her boy, Angus. He and Royal Princess Clover had produced a
number of puppies. Jean called all of those puppy buyers and
since she was on a roll and knew I was looking at other "eligible
males," for Kyra, she did Retroactive Test Matings for a couple
of others too. With the calls Jean made, and the surveys
returned via e-mail or telephone, we now had 1,000 dogs. (And
would you believe they are still trickling in!)
Finally, I acknowledge EVERYONE who
took the time to complete the survey and return it to either Sue
Martin or to me. Thanks to Sue Martin of the Scottish Terrier
Club of America for allowing the first batch of surveys to be
returned to her home and thereby maintain anonymity. And to my
husband, Dick, whose on-going support is obvious to everyone who
knows him and who would sing out as he came in the door from the
Post Office, "You've got surveys."
EXPLANATION OF THE
SURVEY
RESULTS CHART
General
We have 1,000 dogs in
our survey. Approximately 34% of these dogs came from breeders;
the remaining 66% came from pet owners. Of the 1,000 dogs, 40%
(401 dogs) were affected with one or more of the 57 Genetic
Defects listed on the chart; conversely 60% (599 dogs) were
unaffected. All of the genetic traits listed on the chart were
reported in at least one dog. Remember that in Dr. Padgett's
book, "The Control of Canine Genetic Disease," he listed 138
diseases for the German Shepherd Dog. So, while 57 diseases for
our dogs may seem like a lot, it falls way short of 138.
An important number to
remember is 7.1! This represents the average number of defects
carried in each of our dogs. Does this surprise anyone? What
this means is that whether you know it or not, your beautiful
dog carries the genes to pass along, on an average of 7.1
different genetic defects to its offspring. Dr. Padgett's work
and the results of this survey will help you to identify these
traits and breed healthier dogs.
Explanation of Columns
The first
column is the number of dogs reported with "diagnosed genetic
conditions." If there was doubt that a vet diagnosed the
condition, it couldn't be included. There were many other
conditions affecting our dogs that are not genetic and,
therefore, are not included in this chart (see the list later in
this report).
The second
column is the Mode of Inheritance. "Und" means undetermined. "R"
means it is a recessive trait. 'Poly' means Polygenic (more than
one gene is involved), "D" means dominant and the one with a "?"
indicates there is still uncertainty about the mode of
inheritance.
The third
column indicates the % of dogs affected with the disease per 100
dogs. For example 1.0 signifies 1 in 100 dogs is affected with
the disease.
The fourth
column is the one you will want to learn to use and become very
familiar with. This column was figured by using the
Hardy-Weinberg Law. Based on this law, a formula was used to
determine a guesstimate of carrier frequency in our general
population of White Shepherds. One way to interpret the meaning
of this column is to understand that if you randomly pick a dog
for your bitch, this column indicates the risk that the dog you
pick will be a carrier of a particular disease. For example, the
risk for Esophageal Hypomobility in the general population of
White Shepherds is 6.2%. If you have picked a mate that you know
based on your research is "clear" for that disease, you reduce
the risk to zero.
Worksheet
Following the chart is a page entitled "Using
the Genetic Trait Worksheet." I put this together when I was
trying to find the best mate for Kyra. Dr. Padgett thought the
worksheet was helpful and so I decided to include it with the
report. I've included a blank one you can copy and one with an
example of a hypothetical pair of dogs: "Beauty and the Beast."
I've also included the chart from Dr. Padgett's book (with his
permission, of course) that shows you the risk your dog carries
if it is related to an affected dog. The numbers you see next to
the genetic traits on the worksheet are derived from this chart.
I strongly recommend that you buy a copy of Dr. Padgett's
book so you will have all the tools at your fingertips.
Research
After you have
researched your bitch's pedigree and discovered, on average of
7.1 defects, you then call the prospective owner of the dog you
are considering. Obviously, after watching Dr. Padgett's video
and reading this report, they will either have their list ready
or be working on it. (We hope!) Then you go to the chart listing
all our WS conditions and find the carrier frequency. You write
this % in the appropriate column. It is highly likely that the
two canines will not have all the diseases in common. For any
disease your bitch carries that the dog does not, the carrier
risk becomes zero, less than the carrier risk for the general
population. For those diseases they both carry, you need to see
whether their risk is lower than the risk of a random mate (the
carrier frequency column), and or decide that the risk is one
you are willing to take.
If you decide the risk
is one you think you are willing to take, use the formula to
determine the risk of each puppy being affected with the
disease. Then, make your decision.
Keeping
Records
If you have been a breeder who has kept records
of all diseases thrown by your dogs, you are ahead of the game.
If you have not, you will have to gather records, go back
through the pedigrees, call other breeders, and call puppy
buyers. The good news is that you only have to do this once and
from then on, keep good records. Since we buy dogs from each
other, we can help each other gather the information. The
biggest job that you have to do is go back and call every puppy
buyer you can locate and find out whether your puppy is healthy
or whether it is affected with one or more genetic defects. Some
are easy to pinpoint like the missing teeth, umbilical hernias,
etc. Others need to have been diagnosed by a veterinarian. There
are at least a dozen more probable cases of hip dysplasia that
we could not include because the dog had not been diagnosed by a
vet. Once you accumulate this data, you will have the facts you
need right at your fingertips to help make good breeding
decisions.
Summary
The bottom
line is that dogs have defects just like we do. We can't make
good breeding decisions if we don't know what defects they
carry. We can't know what they carry unless we tell each other
and/or register the diseases in an open registry like Genetic
Disease Control. We won't reduce the incidence of disease in our
dogs until we make some of these changes. Information on the
Genetic Disease Control Registry follows the Worksheet.
PET
OWNERS (NON BREEDERS)
I think you may find the
previous information about our breed quite interesting. Since
you are not a breeder, however, you may think it doesn't really
affect you -- or does it? If the information could help you in
selecting your next puppy, how would it help?
It would help because you
are now a more informed buyer. Any breeder who would tell you
there are no genetic defects in their line would not be telling
you the truth. I don't mean they would necessarily be telling
you an untruth – some of them did not have the knowledge to
determine these risks before we did this survey. How do you know
this for sure? Because, as a result of this survey, we "KNOW"
that each one of our dogs carries on the average of 7.1 genetic
defects. And, you would know that if your breeder selected a
breeding pair that didn't carry the SAME genetic defects, the
puppy you buy from that litter is probably going to be healthy.
Your breeder would even be able to tell you the likelihood the
puppy may have an Umbilical Hernia or Missing Teeth in the event
both dogs did carry these defects but were otherwise very
compatible. Or, if you've had the good fortune of living with a
healthy dog from a breeder you trust, you know that breeder is a
good bet to buy from again.
The breeder you want to
run away from and don't go back to would be the one who tells
you they have totally healthy lines and have never had any
genetic defects. It could be they don't follow-up on their dogs.
In the near future we plan
to provide a list of White Shepherd Genetic conditions that you
can take with you when you take your puppy to the vet. Now that
we know exactly what affects our dogs, maybe we can help take
the guesswork out of a diagnosis.
AMERICAN WHITE
SHEPHERD ASSOCIATION
2000 HEALTH
SURVEY RESULTS CHART
Digestive System
|
Digestive System |
Affected Dogs |
Mode of Inheritance |
Frequency % per 100 |
Guesstimate % Carrier
Frequency |
|
Esophageal
Hypomobility |
1 |
Und |
0.1/ 100 |
6.2 |
|
Gastric Dilatation –
Volvulus |
5 |
Und |
0.5/ 100 |
13.2 |
|
Idiopathic Canine
Colitis |
6 |
Und |
0.6/ 100 |
14.2 |
|
Megaesophagus --
Esophageal Achalasia |
1 |
R Und |
0.1/ 100 |
6.2 |
|
Perianal Fistula
(Anal Furunculosis) |
1 |
Und |
0.1/ 100 |
6.2 |
|
Small Intestinal
Bacterial Overgrowth Syndrome |
7 |
Und |
0.7/ 100 |
15.5 |
Behavioral
Problems
|
Behavioral Problems |
Affected Dogs |
Mode of Inheritance |
Frequency % per 100 |
Guesstimate % Carrier
Frequency |
|
Aggressiveness
(Excessive) |
16 |
Und |
1.6/ 100 |
22.6 |
Cancer
|
Cancer |
Affected Dogs |
Mode of Inheritance |
Frequency % per 100 |
Guesstimate % Carrier
Frequency |
|
Breast |
4 |
Und |
0.4/ 100 |
11.8 |
|
Malignant
Histiocytosis |
1 |
Poly/Und |
0.1/ 100 |
6.2 |
|
Hemangeosarcoma |
3 |
Und |
0.3/ 100 |
10.5 |
Hormones - Endocrine Disease
|
Hormones - Endocrine
Disease |
Affected Dogs |
Mode of Inheritance |
Frequency % per 100 |
Guesstimate % Carrier
Frequency |
|
Hypothyroidism
--Autoimmune Thyroiditis |
6 |
R Und |
0.6/ 100 |
14.2 |
|
Primary
Hypo-adrenocorticism (Addison's Disease) |
2 |
Und |
0.2/ 100 |
8.4 |
Heart and Vascular System
|
Heart and Vascular
System |
Affected Dogs |
Mode of Inheritance |
Frequency % per 100 |
Guesstimate % Carrier
Frequency |
|
Inherited Ventricular
Tachycardia |
1 |
Poly |
0.1/100 |
6.2 |
|
Mitral Valve Defect
(MVD Mitral Stenosis) |
1 |
Und |
0.1/100 |
6.2 |
|
Patent Ductas
Arteriosus PDA |
3 |
Poly |
0.3/ 100 |
10.5 |
|
Pulmonic Stenosis PS |
1 |
Poly |
0.1/100 |
6.2 |
|
Subaortic Stenosis |
5 |
Poly |
0.5/ 100 |
13.2 |
Immune System Diseases
|
Immune System
Diseases |
Affected Dogs |
Mode of Inheritance |
Frequency % per 100 |
Guesstimate % Carrier
Frequency |
|
Atopic & Contact
Dermatitis |
16 |
Und |
1.6/ 100 |
22.6 |
|
Autoimmune Hemolytic
Anemia |
1 |
Und |
0.1/ 100 |
6.2 |
|
Demodicosis Demodex |
11 |
Und |
1.1/ 100 |
18 |
|
Discoid Lupus
Erythematosus (DLE) |
1 |
Und |
0.1/ 100 |
6.2 |
Skin Diseases - Allergies
|
Skin Diseases -
Allergies |
Affected Dogs |
Mode of Inheritance |
Frequency % per 100 |
Guesstimate % Carrier
Frequency |
|
Acral Mutilation
Syndrome |
3 |
Und |
0.3/ 100 |
10.5 |
|
Dudley Nose |
8 |
Und |
0.8/ 100 |
16.2 |
|
GSD Pyoderma |
3 |
Und |
0.3/ 100 |
10.5 |
|
GSD Footpad Syndrome |
4 |
Und |
0.4/ 100 |
11.8 |
|
Pemphigus Foliaceus |
1 |
Und |
0.1/ 100 |
6.2 |
|
Primary Seborrhea |
2 |
Und |
0.2/ 100 |
8.4 |
|
Umbilical Hernia |
39 |
R Poly |
3.9/ 100 |
32.0 |
|
Vitiligo |
3 |
Und |
0.3/ 100 |
10.5 |
Liver - Pancreas
|
Liver - Pancreas |
Affected Dogs |
Mode of Inheritance |
Frequency % per 100 |
Guesstimate % Carrier
Frequency |
|
Exocrine Pancreatic
Insufficiency |
5 |
R |
0.5/ 100 |
13.2 |
|
Fibrotic Myopathy |
1 |
Und |
0.1/ 100 |
6.2 |
Nervous System Diseases
|
Nervous System
Diseases |
Affected Dogs |
Mode of Inheritance |
Frequency % per 100 |
Guesstimate % Carrier
Frequency |
|
Degenerative
Myelopathy |
5 |
Und |
0.5/ 100 |
13.2 |
|
Epilepsy |
7 |
R Und |
0.7/ 100 |
15.5 |
Eyes
|
Eyes |
Affected Dogs |
Mode of Inheritance |
Frequency % per 100 |
Guesstimate % Carrier
Frequency |
|
Cataracts |
2 |
R Und |
0.2/ 100 |
8.4 |
|
Corneal Dystrophy |
1 |
R |
0.1/ 100 |
6.2 |
|
Dermoid |
1 |
R? Und |
0.1/100 |
6.2 |
|
Eversion of the
Nictitating Membrane |
1 |
R Und |
0.1/ 100 |
6.2 |
|
Imperforate Lacrimal
Punctum |
12 |
Und |
1.2/ 100 |
19.6 |
|
Pannus (Superficial
Stromal Keratitis) |
4 |
Und |
0.4/ 100 |
11.8 |
Reproductive
Diseases
|
Reproductive Diseases |
Affected Dogs |
Mode of Inheritance |
Frequency % per 100 |
Guesstimate % Carrier
Frequency |
|
Cryptorchidism |
12 |
R/ Und |
1.2/ 100 |
19.6 |
Skeletal Diseases
|
Skeletal Diseases |
Affected Dogs |
Mode of Inheritance |
Frequency % per 100 |
Guesstimate % Carrier
Frequency |
|
Cleft Lip/Cleft
Palate |
2 |
Poly Und |
0.2/ 100 |
8.4 |
|
Dwarfism, Pituitary |
1 |
R Und |
0.1/ 100 |
6.2 |
|
Ears not standing |
11 |
Und |
1.1/ 100 |
18.0 |
|
Hip Dysplasia |
49 |
Poly |
4.9/ 100 |
34.3 |
|
Hypertrophic
Osteodystrophy |
1 |
Und |
0.1/ 100 |
6.2 |
|
Lumbosacral
Malarticulation |
1 |
Und |
0.1/ 100 |
6.2 |
|
Lumbosacral Stenosis
(Spinal Stenosis) |
2 |
Und |
0.2/ 100 |
8.4 |
|
Luxation of the
Tarsal, Metatarsal, & Intertarsal Joints |
2 |
Und |
0.2/ 100 |
8.4 |
|
Missing Teeth |
36 |
R/ Und |
3.6/ 100 |
30.0 |
|
OCD - Elbow Dysplasia
FCP - OC |
13 |
Poly |
1.3/ 100 |
19.6 |
|
OCD - Elbow Dysplasia
(UAP) |
4 |
Und |
0.4/ 100 |
11.8 |
|
OCD - Degenerative
Joint Disease |
11 |
|
1.1/ 100 |
18.0 |
|
Overshot Jaw |
1 |
R Und |
0.1/ 100 |
6.2 |
|
Panosteitis |
53 |
Und |
5.3/ 100 |
35.4 |
|
Premature Closure of
the Ulna |
1 |
R |
0.1/ 100 |
6.2 |
|
Spondylosis Deformans |
2 |
Poly |
0.2/ 100 |
8.4 |
Urinary System
Diseases
|
Urinary System
Diseases |
Affected Dogs |
Mode of Inheritance |
Frequency % per 100 |
Guesstimate % Carrier
Frequency |
|
Hypospadias |
1 |
Und |
0.1/ 100 |
6.2 |
|
Uroliths (Struvite) |
1 |
Und |
0.1/ 100 |
6.2 |
TOTAL DOGS IN SURVEY: 1000
AFFECTED DOGS: 401 (40%)
UNAFFECTED DOGS: 599 (60%)
% of Dogs reported belonging to breeders: Approximately 34%
% of Dogs reported belonging to nonbreeders: Approximately
66%
NON-GENETIC
PROBLEMS
General
The oldest dog reported in our
survey period was 18 years old. The same person had a White that
lived to be 21 but had died prior to the start of the survey
period.
The following is a list of
problems that are not genetic in origin; therefore they are
not included in the survey. If detail is wanted, feel free to
contact me.
Allergies
Lick sores, bacterial skin infections, nose rash, and hot
spots were reported.
Anal Gland Problems
A female and three males were reported to have anal gland
problems.
Benign Tumors
Three females and four males were reported with benign tumors
or cysts.
Cancer
Dr. Padgett points out that one out of four dogs will develop
cancer – same as us. The one cancer known to be genetic and the
two suspected of being genetic are reported on our Survey Chart.
Others reported were brain cancer, Hemagiopericytoma,
Pancreatic, site specific cancer, Bone Cancer, Lymphoma, Colon
Cancer, Fibrosarcoma, blood vessels and spleen, Liver Cancer,
spine, growths on lip, mouth, gums, nose, leg, lung, and type
unknown.
Ears
Dogs reported with ear infections, ear mites, and ear aches.
Eyes
Reports of eyes that tear, epithelial folds, itchy eyes, and
runny eyes.
Heart
Infection of lining of the heart reported, a couple of
murmurs with no attendant problems, congestive heart failure,
and heart disease without a specific diagnosis.
Intestinal
A female with Small Intestinal Malabsorption reported and
three with nervous stomachs.
Lyme Disease
Three dogs reported with Lyme disease
Reproductive
Females with bacterial infections of reproductive organs,
split heats, abnormally long heat cycles, erratic seasons,
pyrometria, constant yeast infections, unable to reproduce,
brittle uterus, endometriosis and fissures reported. Males with
prostate problems requiring neutering.
Spine
Spinal deterioration after age 11, embolism on spine, and
spinal instability reported.
Stool Eaters
Three female Stool Eaters
Virus
A female died within 48 hours of becoming ill; vets believed
she had CoonHound Virus
Weight Management
A male cannot keep on weight
Worms, etc
Giardia, ringworm, coccidia, Parvo and bouts with worms
reported.
Miscellaneous
Sporadic vomiting, Valley Fever, kidney failure due to
dehydration, internal bleeding, strangles, unhealed sore,
inflamed liver, RACL, torn meniscus, skull improperly closed,
anterior cruciate ligaments torn, and hematomas reported.
Some Comments to
Share from Survey Respondents:
Thank you for caring for this most
beautiful and majestic breed.
Spoiled rotten but no disease
diagnosed
Exceptionally healthy four year old
White GSD who loves to jump, play, and try to catch squirrels
She is trim, tall and weighs 90
lbs. A real beauty. Her breeder did a great job.
No diseases have been diagnosed in
any of my dogs, Thank God!
My White Shepherd is very sweet,
loving, and intelligent.
This is the healthiest dog I have
ever owned (5 years old).
I love the White Shepherd nature. I
have had 4 in total.
Thank you for doing this survey --
32 years W.S.
All of my dogs are very healthy.
Also owned two other females who
lived to be 14 & 16 years old. Neither had diseases…during their
life.
Greatest dog I have ever been
blessed with.
My dog will be 6 years old June 2.
He is 29 inches, weighs 85 pounds, and plays Frisbee 2X a day.
He is gorgeous and healthy. We are
very fortunate.
My dog has been very healthy (thank
God).
Thankfully our love is a very
healthy, happy loving dog and loves to play with other dogs.
No problems. She is a sweet lady –
thanks.
No G.D. diagnosed. We own a happy,
healthy (Frisbee fanatic white shepherd).
My shepherd is more human than
animal. He is a pride to his lineage. I love him with all my
heart.
My dog is beautiful and healthy.
She is very loving and protective and unbelievably intelligent.
I have had dogs all my life and he
is one of a kind.
Very healthy, slightly nervous,
otherwise an excellent pet. We will always own a White Shepherd.
Other than seasonal allergies the
healthiest dog I have ever owned.
My 10-year-old wonderful dog is the
healthiest dog I have ever owned.
Thank God I have a very healthy
dog. She is my pal, companion and my protector and I love her.
Extremely healthy dog. Thanks for
doing this survey. The best breed in the world.
NERVOUS – FEARFUL – SHY – TIMID
In his book, Dr. Padgett
lists three categories under Behavioral Diseases. According to
his sources, the GSD has a pre-disposition to one of them. That
one is Aggression, which is defined as extremely assertive or
forceful with other dogs and people, may attack without
reasonable provocation. Sixteen dogs in our survey were reported
to be aggressive (some just dog aggressive) and included in this
category in the survey.
Some of our breeders feel
that the timid or soft dog is another category of behavior that
may also be genetic in origin. Since this was not a trait
determined to be genetic for the GSD by Dr. Padgett's sources,
we could not include it in our survey. Even though this category
could not be included on the list of Genetic Traits of the White
Shepherd, I included a category of Nervous/Fearful so we could
at least see what kind of responses we'd get. This category was
checked off 75 times but often with qualifying remarks. "My dog
is only fearful at first; he is fine once he gets used to you,"
"he's always been shy" and other similar remarks. Most of this
is extremely subjective as opposed to a somewhat easier task of
identifying an aggressive dog.
The 75 dogs reported in
the Nervous/Fearful category indicates that 7.5% of our dogs
have this trait (described a number of ways by people). If this
is, in fact, a genetic trait, we have a carrier rate of 39.4%.
If, after we as a Club discuss the Genetic Defects and feel we
have a problem, we need to decide together how to approach it
and reduce the number of affected dogs. This could be one of
those traits that might be worthwhile to pinpoint on a
geneticists pedigree to see where it occurs and from which lines
of dogs.
Some questions we need to
ask are: Were they properly socialized? Some of the timid or
soft dogs from pet owners may, in fact, be a result of poor
socialization. But we don't know that. On the other hand, if a
very young puppy showed shy/timid/fearful/nervous behavior,
could this be genetic in origin? Do we expect kennel dogs to
exhibit shy, fearful behavior – or only certain lines from
certain parents? Do the same questions apply to the aggressive
dogs? Were the aggressive dogs born this way or made this way?
TABLE 5.6
RISK OF
BEING A CARRIER IF RELATED TO AN AFFECTED DOG
(AUTOSOMAL
RECESSIVE TRAIT)*
|
Relationship |
Degree of
Relationship |
Minimum Carrier Risk |
|
Parent, Progeny |
1 |
100% |
|
Full Brother / Sister |
1 |
66.6% |
|
Grandparents, Aunts,
Uncles, Half-brothers or sisters, Grandchildren |
2 |
50.0% |
|
Niece, Nephew |
2 |
33.3% |
|
Great-grandparent,
First Cousins, Half-aunts and uncles,
Great-grandchildren |
3 |
25.0% |
|
Great-great-grandparents, First Cousin once removed,
Second Cousins |
- |
12.5% |
|
Great-great-great
grandparent, First Cousin twice removed, Third Cousins |
- |
6.25% |
*This chart is used for
Autosomal Recessive Traits as well as Polygenic Traits – the
risk for the Polygenic Trait will be "at least" this percentage.
GENETIC
DISEASE CONTROL
OPEN
REGISTRY
In an Open
Registry, all data on an animal is made available to breeders,
whether the dog is phenotypically normal or is affected with one
or more disease. In contrast, a Closed Registry, such as OFA,
releases information only on those dogs that are phenotypically
normal (phenotype is what you see when you look at the dog).
The Institute for Genetic
Disease Control (GDC) began operations in 1990. It has both an
open disease registry and a research registry. It collects data
able to be of use to a breeder in selecting animals for breeding.
When sufficient data becomes available, all dogs are placed in
an open registry and all information is made available to
breeders.
It provides the following
data:
All data it has on the dog
for which you request information and his/her offspring.
Any information it has on
his/her full brothers and sisters and half-brothers and sisters
(all offspring of the parents of the dog.
Any information it
has on the parents, their full brothers and sisters and
half-brothers and sisters (all offspring
of the grandparents of the dog).
Any information it has on
the grandparents.
In this way, an inquiry
results in full data on the family of the dog you are interested
in, including all titles that the dog, his parents and his
grandparents have earned that are on file.
We need to prioritize
Genetic Defects and we need to decide as a Club that we will
register our breed and our dogs with the GDC. I am currently in
communication with staff at GDC to determine what steps we need
to take to get this task underway. I will keep you informed.
~ Judy Huston
|